Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia
نویسندگان
چکیده
منابع مشابه
Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia.
Subcortical dopamine system dysregulation has been suggested to underlie the positive symptoms of schizophrenia. Recent preclinical investigations and human imaging studies have proposed that the augmented dopamine system function observed in schizophrenia patients may be secondary to aberrant hippocampal activity. Thus, we posit that the hippocampus represents a novel therapeutic target for th...
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Deep brain stimulation (DBS) has successfully advanced our treatment options for putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation, more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially, schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. Thi...
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ژورنال
عنوان ژورنال: International Journal of Neuropsychopharmacology
سال: 2013
ISSN: 1469-5111,1461-1457
DOI: 10.1017/s1461145712001344